摘要
目的探讨β-连结素蛋白(β-caten in)在胰腺癌中的表达及其与预后的关系。方法应用免疫组化法检测胰腺癌中-βcaten in的表达,分析其与胰腺癌临床病理因素的关系及对预后的影响。结果62例胰腺癌患者中,-βcaten in异常表达率为45.2%(28/62)。随分化程度分级由高分化至低分化异常表达率显著升高(P<0.05);-βcaten in的表达与淋巴结转移(P<0.01)和远处转移(P<0.05)亦明显相关;随访24个月,β-caten in正常表达组术后中位生存期为7个月,而-βcaten in异常表达组为6个月,差异有显著性(P=0.0328)。结论β-caten in与胰腺癌预后相关,可作为判断胰腺癌预后的一个指标。
Objective To investigate the expression of β-catenin in pancreatic carcinoma and its significance to the prognosis. Methods The expression of β-catenin was studied using immunohistochemistry,and the relationship between β-catenin and the survival time of patients with pancreatic carcinoma was analysed. Results The positive rate of β-catenin in pancreatic carcinoma was 45.2% （28/62）. The expression of β-catenin was correlated with differentiation, lymph node metastasis and lymphatic invasion of the carcinoma. The patients with normal expression of β-catenin survived longer than those with abnormal expression（P = 0.0328）. Conclusions The expression of β-catenin is related with prognosis and is an independent prognostic factor in pancreatic carcinoma.
出处
《中国肿瘤临床与康复》
2006年第2期100-103,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
