博来霉素A_5病灶内注射治疗血管瘤样病变

Intralesion injection of bleomycin A_5 for the treatment of angioma-like anomalies

目的探讨博来霉素A5病灶内注射治疗血管瘤样病变的方法和疗效.方法自1997年7月至2004年9月用博来霉素A5局部用药治疗血管瘤样病变患者28例,其中体表病变21例,口腔和咽喉部位病变7例,每3周1次.结果儿童17例真性毛细血管瘤注射2～3次后病灶完全消失,1例海绵状血管瘤注射3次后缩小70%;7例成人口腔和咽喉部位病变注射3次后病灶都完全消失,3例成人体表海绵状血管瘤注射3次后病灶都缩小60%～70%.结论博来霉素A5病灶内注射是治疗血管瘤样病变安全、有效的方法.

Objectives To investigate the techniques and outcomes of intralesion injection of bleomycin A5 for the treatment of angioma-like anomalies. Methods From July, 1997 to September, 2004, intralesion injections of bleomycin A5 , one time every 3 weeks, were used for the treatment of 28 patients with angioma-like anomalies, of which 21 were skin lesions, 7 were located in mouth-pharynx area. Results The capillary hemangiomas disappeared after 2 or 3 intralesion injections in 17 children, cavernous hemangioma shrank by 70% after 3 injections in 1 child,vascular anomalies located in mouth-pharynx area were cured after 3 injections in 7 adults, cavernous hemangioma shrank by 60% -70% in three adults. Conclusion Intralesion injection of bleomycin A5 is a safe and effective modality for the treatment of angioma-like anomalies.