摘要
本实验采用小剂量递增法（吗啡剂量从２５ｍｇ·ｋｇ－１增至１５０ｍｇ·ｋｇ－１），皮下注射给药４．５ｄ，经纳洛酮（５ｍｇ·ｋｇ－１）催瘾后，得到理想的小鼠戒断模型。采用上述小鼠模型，观察东莨菪碱、樟柳碱、尼莫地平和硝苯地平对吗啡成瘾小鼠戒断综合症的治疗效果。结果表明，东莨菪碱和樟柳碱（０．５－５ｍｇ·ｋｇ－１）明显抑制小鼠的跳台反应。剂量为４０－８０ｍｇ·ｋｇ－１的尼莫地平和硝苯地平亦可明显抑制小鼠的跳台反应。樟柳碱和尼莫地平的无效剂量（０．１ｍｇ·ｋｇ－１＋３０ｍｇ·ｋｇ－１）合用后，显著降低小鼠的跳台反应。提示钙离子的流入与胆碱能神经在戒断症状的治疗中相互关联，值得进一步研究。
The mouse dependence model was established by gradually increasingdoses of morphine (from 25 mg. kg-1 to 150 mg. kg-1, 4. 5 days). The effects of nimodipine (Nim), nifedipine (Nif), scopolamine (Sco) and anisodine (Ani) on withdrawal were studied in naloxone - precipitated mice. Nif 40 -- 80 mg. kg-1, Nim40 -- 80mg. kg-1, Sco 0. 5 -- 5 mg. kg-1 and Am 0. 5 -- 5 mg. kg-1 were able to inhibit thejumping. While neither Am 0. 1 mg. kg-1 nor Nim 30 mg. kg-1 was effective in thismodel but combination of them decreased jumping.
关键词
药物依赖
吗啡依赖
钙拮抗剂
抗胆碱药
戒毒
morphine
withdrawal syndrome
calcium channel inhibitor
anticholinergic drug
