摘要
本文对22例窒息患儿生后七天内血皮质醇（F）和醛固酮（A）进行动态测定，并随机选择10例患儿给予地塞米松每次0．5～1mg／kg治疗。结果提示：1．新生儿肾上腺皮质分泌功能已趋成熟，并有较好的应激能力，但其调节能力较差。2．激素治疗造成血F进一步升高，加重了本已存在的水平紊乱，在并发症方面，治疗组（尤其使用≥5天者）发生了30％的严重感染，而对照组无类似情况、故我们综合国内，外文献，建议小剂量地塞米松对窒息患儿的治疗是没有必要的，结果只能是弊大于利。
Blood cortisol (F) and aldosterone (A) levels were measured ongoing in 37 perinatal newborns The subjects were divided into three groups: normal control (n=15) asphyxiated control (n=12) and asphyxiated dexamethasone (0.5-1mg/kg, treatment group (n=10). The results showed that The cortical secretion by newlorn was mature and its stress was high, but the autoregulatory alility was weak. The results also showed that the average cortisol level was significantly higher in＜24h、5day t:3.64, 2.088 P＜0.05),than that in asphyxiated control group and 30 percent severe secondary infection was occurred in asphyxiated dexamethasone treatmcnt group. This study suggests that dexamethasone therapy is unecessary in asphyxia
出处
《新生儿科杂志》
1996年第1期1-3,共3页
The Journal of Neonatology
