新生儿窒息血浆前列腺素血栓素变化

CHANGES OF PLASMA PROSTACYLIN AND THROMBOXANE IN NEWBORNS WITH ASPHYXIA

本文测定28例新生儿窒息的前列腺素、血栓素代谢产物6－K－PGF1α、TXB2生后24小时及72小时血浆水平，且并与16例无缺氧性疾病的新生儿进行对照。结果表明三组的血浆6K－PGF1α生后24小时测值均比生后72小时高。且重度窒息组生后24小时测值明显高于另两组。血浆TXB2生后24小时和72小时测值均以重度窒息组增高明显。且重度窒息组中有脑损伤者72小时6－K－PGF1α、测定值高于无脑损伤组。提示血浆6－K－PGF1α、TXB2水平可作为新生儿缺氧及其严重程度判断的灵敏指标之一。

This paper reports the result of the plastna prostacyclin (6-K-PGF1 α) thromboxane (TXB2) test in 28 cases of the newborns with asphyxia after born 24 hr and 72hr. The concentration of plasma 6－K－PGF1α and TXB2 in the newborns with severe asphyxia has been shown much higher than that in the normal ones and slight asphyxia ones. In the severe asphyxia group, the level of plasma 6-K-PGF1α and TXB2 of the newborns with brain injury is very high