脑卒中后抑郁症的前瞻性研究

A prospective study of depression after cerebral strokes

对81例初发大脑半球卒中患者于急性期和发病后3、6、12个月进行连续随访,旨在观察脑卒中后抑郁症的发生、演变情况及影响抑郁症的因素。结果显示:(1)抑郁症在病后第3个月时总体评分最高,以后随时间推移有下降趋势;(2)病灶最前点愈接近额极,对抑郁症的影响愈大;(3)神经功能缺损的严重程度、合并症、生活状态、照料人是影响抑郁症的主要相关因素,而病灶所在的大脑半球、CT 扫描上显示的陈旧病灶、性别、年龄等与抑郁症的发生无明显相关性。

Among 81 patients there were 61 who had a cerebral hemispheric stroke for the first time and survived for more than 12 menths were followed up in order to observe the incidence and evolu- tion of depression after the strakes and the factors related to the depression.The results were as folows. (1)Deparession scores were the highest within 3 months after the strokes and decreased gradually after- wards.(2)The distance from the frontal pole of the cerebrum to the most anterior point of the intrac- erebral lesion was related with the severity of the depression after the strdses.(3)The severity of the neurological deficits,the quality and progress of life,and complications during the recovery period were among the main relating factors in positive correlation with the severity of the post-stroke depression. There was no definite correlation between the severity of the post-stroke depression and the location of the intracerebral stroke lesions,other ischmic lesions shown in the CT scans,and the patient's sexes and ages.