克矽平大容量全肺灌洗治疗煤矽肺2年疗效对照观察

The Effect of Treatment by Whole Lung Lavage with Polyvinylpyridine - N -oxide Solution in Anthracosilicosis Patients

克矽平灌洗液用于大容量全肺灌洗治疗尘肺,不仅能洗出滞留在肺脏的粉尘等致病物质,使药液直接到达病灶。本文通过21例治疗及21例对照,经二年疗效动态观察,结果表明:全肺灌洗可洗出滞留在肺脏一定量粉尘,其洗出量快型尘肺明显高于慢性尘肺(P<0.01),但临床症状、肺功能、X线胸片观察二年时未见明显不同,半年、一年时胸片显示有效,认为是克矽平作用。以上结果提示,该项技术适用于早期快型尘肺,但仍需作较长时间观察。

42 anthracosilicosis patients were devided into two groups ,one group was treated with whole lung lavage with polyvenylpyridine - N-oxide (P204)solution ,the other one was a control group. After two - year treatment .the results showed that a certain quantity of dust could be removed by whole lung lavage ,and the dust was removed significantly much more from acute pneumoconiosis patients than from chronic ones (P< 0. 01),but there was no significant difference in clinical manifestation between two groups. It is suggested that this method of treatmemt might be more effective for pneumoconiosis patients in early stage or in acute form.