369例病毒性肝炎患者抗-HEV的检测与分析

INVESTIGATION OF HEPATITIS IN 369 CASES OF VIRAL HEPATITIS

369例病毒性肝炎患者血清中抗－HEV的检出率为16．53％（61／369），其检出率与患者年龄密切相关，但与患者性别及发病季节无相关性。无论是甲肝、乙肝还是丙肝均可重叠感染戊型肝炎病毒（HEV）。乙肝与HEV重叠感染者症状持续时间长、肝功能损害明显。通过比较甲型肝炎与戊型肝炎发现：前者以青壮年多见，有48．3％患者黄疸先消退，尔后谷丙转氨酶（ALT）恢复正常；而后者多见于中老年，有54．6％ALT先恢复正常，尔后黄疸消退。

Hepatitis E (HE) was investigated in 369 cases of viral hepatitis in 1992. The antibodies to hepatitis E virus (anti-HEV) in these patients sera were measured by ELISA. The positive rate was 16. 53% (61/369) and was correlated with age but not with seasons and sexes. The study confirmed that HEV can exist as superinfection or coinfection with HAV, HBV and HCV. The clinical symptom and course were long in patients with HBV overlapping. By comparing HE with HA, we found that: (1) HA occured in young or middle age and 48.3% patients' serum bilirubin (SB) returned to normal than alanine transaminases (ALT) did. (2) HE occured in adult especially in old age and ALT returned to normal earlier than SB did.