胃癌及癌前病变组织中AgNOR数量及形态变化的研究

The Number and Morphology of AgNOR in Gastric Carcinoma and PrecancerousLesions

应用核仁组成区染色技术研究正常胃粘膜、胃粘膜异型增生、早期胃癌及进展期胃癌的核仁组成区（ＡｇＮＯＲ）数量和形态变化，发现正常胃粘膜ＡｇＮＯＲ计数最低、形态无畸形，随胃粘膜病变的进展，ＡｇＮＯＲ计数逐渐升高，且形态上的畸形程度也随之增加。ＡｇＮＯＲ计数与胃癌的浸润呈正相关，与胃癌的组织分化程度皇负相关，ＡｇＮＯＲ计数高的胃癌易发生淋巴结转移。结果提示，用ＡｓＮＯＲ计数，同时结合ＡｇＮＯＲ畸形程度有助于鉴别中、重度胃粘膜异型增生与早期胃癌。

Normal gastric mucosa,mucosal dysplasia,early and advance gastric carcinoma were studied with the silvcr stain-ing of nucleolar organizer regions(AgNOR).The lowest nean count and no deformity of AgNOR were found in normal mucosa.The mean count and deformity degree of AgNOR increased gradually with the progression of gastric tnucosal lesions,The meanAgNOR count was positively related to the infiItrative depth of gastric carcinoma and reversely related to the defferentiation ofgastric carcinoma The gastric carcinoma with higher mean AgNOR count was easy to metastasize to lymph node,The crcsult sug-gested that the method of AgNOR count together with the AgNOR deformity degree might be helpful to distinguishing early gas-tric carcinoma frorn middle and severe dysplasia,and that the AgNOR count could be used as a quantitatlve indecator for the as-sessment of the biological behavior and gastric carcinoma.