宫颈良、恶性病变核仁组成区蛋白定量与宫颈癌预后的研究

Quantitative Study of AgNOR in Benign and Malignant Cervical Lesions and Its Relation to the Prognosis of Cervical Cancer

应用核仁组成区蛋白嗜银（ＡｇＮＯＲ）技术，对１０９例宫颈良、恶性病变进行了ＡｇＮＯＲ定量研究。结果表明：１．慢性宜颈炎、宫颈非典型增生、宫颈鳞癌三种病变的ＡｓＮＯＲ均值有显著差异（Ｐ＜０．０１）。２．宫颈鳞癌组织学１级ＡｇＮＯＲ计数低于组织学Ⅱ级（Ｐ＜０．００１）。３．随访１０年以上的７３例宫颈鳞癌患者，核仁组成区蛋白高均值组（≥５）的患者生存时间显著短于低均值组（＜５）（Ｐ＜０．０５），１０年生存率分别为１８％与４６％。作者认为，ＡｇＮＯＲ计数可作为一种新的肿瘤定量指标，在宫颈良、恶性病变的鉴别诊断、选择最佳治疗方案、推测宫颈癌预后等方面具有重要的临床价值。

Quantitative study of Argyrophilic neucleolar organizer region(AgNOR)was performed on 109 cases of cervicalbenign and malignant lesions.We found that the mean value of AgNOR in the three different lesions of chronic cervicitis,cervicalatypical hyperplasia and cervical squamous carcinoma has a significant difference(P<0.0l),and the count of AgNOR in histologicgrade Ⅰ squamous carcinoma is lower than that in grade Ⅱ(P<0.00l).The l0-years survival rate of cervical squamous carcinomapatients with mean value of AgNOR≥5(18%)is significantly lower than those<5(46%)(P<0.05).These results suggested thatthe count of AgNOR might be considered as a new quantitive marker in differentiating diagnosis of benign and malignant cervicallesions,chosing optimum treatment schemes,and deducing the prognosis of cervical carcinoma.