摘要
胃肠道平滑肌肉瘤（ＬＳ）５１例，其中食管２例、胃１８例、小肠２２例、大肠９例。临床症状缺乏特征性。核分裂数均≥１个／１０ＨＰＦ，过半数的ＬＳ可见到边缘浸润、瘤巨细胞及幼稚瘤细胞。Ｖｉｍｅｎｔｉｎ及Ｆｉｂｒｏｎｅｃｔｉｎ阳性率１００％，Ｄｅｓｍｉｎ２２％，Ｃｙｔｏｒｅｒａｔｉｎ全部阴性，Ｓ－１００３／８阳性，Ｐ５３阳性率４４％。ｐ５３蛋白的表达在生存组与死亡组之间有显著差异，在ＬＳⅠ级与Ⅱ、Ⅲ级之间亦有显著差异，但其表达与肿瘤体积、边缘浸润、幼稚瘤细胞出现及病人的生存时间等无关。
The expression of p53 protein in leiomyosarcoma(LS)of the digestive tract and its correlation to grade and prog-nosis were studied in 51 cases by immunohistochemical technique.44%cases stained positive for P53,protein,There was a signifi-cant difference in the rate of the survival group and deathgroup(P<0.05).The positive rate of gradeⅡ and Ⅲ was also signifi-cantly different from gradeⅠ(P<0.05)The results suggested that P53 protein status could be used as an indicator of the gradeand prognosis of LS in digestive tract The data were also examined histologically and immunohisto chemically for vimentin.desmin,S-100.fibronectin and cytoReratin.LS was c`erized by cellular atypia,more cells in mitosis and invasion to adiacentnormaltissue.
