喉癌患者围手术期血清SIL－2R浓度的测定及其与预后的相关性研究

Serum sIL-2R Level in Perioperative Period and Its Relationship with Early Re-currence in Laryngeal Carcinoma

本文测定了３２例喉癌患者围手术期血清可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）的浓度。结果表明，喉癌组较对照组明显什高（Ｐ＜０．０１），在喉癌中，声门上型及混合型较声门型为高，临床ⅢⅣ刊期病变较ⅠⅡ期病变显著增高（Ｐ＜０．０５）。手术后１日较术前明显增高，至１０日则降至术前水平。部分病人术后１０日血清ｓＩＬ－２Ｒ持续增高，与术后１年内复发有明显相关性。

Serum level of soluble interleukin 2 receptor(sIL-2R)was measured during the perloperative period in 32 patientswith laryngeal carcinoma. The results indicated that the serum level of sIL-2R was significantly higher in laryngeal cancer pa-tients than those in normal control group. Of the laryngeal cancer,the level of sIL-2R were higher in the supraglottic type andmixed type than that of glottic type(P<0.01).They were significantly higher in the clinicalⅢ,Ⅳ stages than those ofⅠandⅡ(P<0.05).The sIL-2R levels reach a much higher level one day after operation. Recurrence within one year was related withhigh level of sIL-2R ten days after operation