透明质酸钠在抗青光眼手术中的应用

Application of sodium Hyaluonate in anti-glaucoma operation

目的探讨在小梁切除术结束时向前房注透明质酸钠,以降低术后眼压和预防术后浅前房发生的临床效果。方法观察组29例(31眼)原发性闭角型青光眼,在小梁切除手术结束时前房注透明质酸钠形成正常前房。对照组32例(34眼)原发性闭角型青光眼,在手术结束时前房未注透明质酸钠。结果观察组术后浅前房4眼,占12.50%;对照组术后浅前房16眼,占47.05%,2者经统计学处理有显著性差异(P<0.01)。2组术后眼压被控制正常范围情况比较,差异无统计学意义(P>0.05)。结论青光眼小梁切除术结束时,前房注透明质酸钠,可预防术后浅前房发生,减少术后并发症,提高手术安全性,并且眼压控制效果与前房未注透明质酸钠相近。

Objective To study the effect of sodium Hyaluronate （NAHA） on intraocular pressure and occurence of shallow anterior chamber by injecting after glaucoma trabeculectomy. Methods In the experimental group 29 eases （31 eyes） primary angleclosure glaucoma, NAHA was injected into anterior chamber to form normal anterior chamber at the end of trabeculectomy, and in control group 32 eases （34 eyes） primary angle-closure glaucoma, NAHA was not injected into anterior chamber at the end of trabeculectomy. Results In the experimental group, there were 4 eyes （ 12.50 % ） shallow anterior chamber after trabeculectomy, while in control group, 16 eyes （47. 05%） shallow anterior chamber occured （P 〈 0.01）. There was no significant difference in the controlled normal range of intraocular pressure （P〉 0.05）. Conclusion At the end of glaucoma trabeculectomy, injection of NAHA into anterior chamber could prevent shallow anterior chamber, decrease post-operation complication, and increase the safety of the operation.