眼底荧光血管造影不良反应相关因素探讨

Study on the correlative factors of adverse reactions in fundus fluorescein angiography

目的探讨眼底荧光血管造影（fundus fluorescein angiography，FFA）不良反应发生的相关因素。方法对连续进行的2078例FFA中发生的不良反应情况进行统计分析。结果不良反应发生率为5．77％，大部分在注射荧光素钠后2min内发生并在2min内好转，最常见的不良反应为恶心呕吐（79．17％）、荨麻疹（12．50％）及晕厥（4．17％）。在本文涉及的影响因素如年龄、性别、气候、药品批号、有无“诱导”等中，仅年龄1项在统计学上有显著差异（t=4，82，P〈0．01），并以20～40岁年龄组最为多发（10．17％）。结论FFA是基本安全的眼科检查手段，年龄是不良反应发生最重要的影响因素，过敏反应和精神紧张、迷走兴奋可能是主要的发病机制。

Objective To study the correlative factors of adverse reactions in fundus fluorescein angiography （FFA）. Methods Adverse reactions happened in 120 patients among 2 078 successive cases of FFA were analyzed. Results The incidence of adverse reactions was 5.77%. Most of the adverse reactions happened within 2 minutes after the injection of uranin and alleviated in 2 minutes. The most common adverse reactions were nausea and vomiting （79.17%）, followed by urticaria（ 12.50% ） and syncope （4.17%）. Among the possible correlative factors such as age, sex, season , the batch of uranin and the factor of inducement, only age showed correlation significantly（ t = 4.82, P （ 0.01 ） with the occurrence of the adverse reactions with the incidence of 10.17% in the young （20-40 years old）.Conclusion FFA is a safe examination and the age of patient is the most important correlative factor of adverse reactions in FFA. Allergic reaction, psychentonia and vagotonia may be the principal pathogenesis of the adverse reactions of FFA.