摘要
背景与目的:恶性纤维组织细胞瘤(Malignantfibroushistiocytoma,MFH)是软组织常见的恶性肿瘤之一,原发于骨者比较少见,其组织来源仍存在争议。本研究旨在探讨原发性骨恶性纤维组织细胞瘤的病理特点、X线特征,以提高对本病影像诊断水平。方法:回顾分析我院1982年1月至2002年6月收治的经病理检查证实的16例原发性骨恶性纤维组织瘤的临床、病理及X线资料。结果:病理表现有多核瘤巨细胞的存在,瘤细胞的多样性,成纤维细胞呈车轮状排列。病理组织由多种细胞成分构成,但以成纤维细胞和组织细胞为主。X线表现以单发性溶骨性破坏为主,肿瘤周围的骨皮质有不同程度膨胀,病灶突破骨皮质形成软组织肿块,骨膜反应或病理性骨折。结论:MFH在病理上和X线影像表现上均呈多样性,无明显特征,但结合临床表现、X线像表现和病理检查能作出诊断。
BACKGROUND & OBJECTIVE: Malignant fibrous histiocytoma (MFH) is a common soft tissue tumor, which rarely occur in the skeleton. Its histological origin still remains controversial. This study was to investigate the pathologic and X-ray features of primary MFH of bone, and provide reference for imaging diagnosis. METHODS. Clinical data and X-ray images of 16 MFH patients, treated from Jan. 1982 to Jun. 2002 in the First Affiliated Hospital of Soochow University, were analyzed retrospectively. RESULTS. Pathologic manifestations of the patients were malignant multinucleated giant cells, pleomorphic and bizarre form of the tumor cells, and wheel-spoke arrangement of the fibroblast-like cells. Pathologically, the tumor tissue was consisted of various kinds of cells, which were mainly fibroblasts and histiocytes. The principal X-ray manifestations included solitary osteolytic changes, cortical expansion around the tumor, the penetration of the cortex with soft tissue mass formation, slight periosteal reaction and pathologic fracture. CONCLUSION. The diagnosis of MFH mainly depends on pathologic examination and X-ray manifestations.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2006年第5期614-618,共5页
Chinese Journal of Cancer
关键词
骨肿瘤
恶性纤维组织细胞瘤
病理学
影像学
诊断
Bone neoplasm
Malignant fibrous histiocytoma
Pathology
Imaging
Diagnosis