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血清非酶糖基化终产物与糖尿病视网膜病变的相关关系 被引量：2

The correlation between the advanced glycation end products (AGEs-P) and diabetic retinopathy
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摘要 96例2型糖尿病视网膜病变(DR)患者,35例2型DM不伴DR患者,以及40例正常对照的研究显示,血清糖基化终末产物的含量与DR病变严重程度呈正相关。 The study of diabetic retinopathy（n=96）, T2DM without retinopathy （n=35） and normal control （n=40） showed that the content of serum AGEs was positively correlated with the severities of diabetic retinoopathy.
作者 胡凯 栾洁 孙子林 钟历勇 王尧 董莉 杨冰全
机构地区 东南大学附属中大医院眼科 东南大学附属中大医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2006年第2期112-113,共2页 Chinese Journal of Diabetes
基金 东南大学医学基金资助项目(XY0026038)
关键词 糖尿病视网膜病变 糖基化终产物 Diabetic retinopathy Glycosylation end producets, advanced
分类号 R587.2 [医药卫生—内分泌] R774.1 [医药卫生—眼科]
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参考文献4

  • 1ASO Y,Inukai T,Tayama K,et al.Serum concentrations of advanced glucation end products are associated with the development of athetosclerosis as well as diabetic mictoangiopathy in patients with type 2 diabetes.Aola-Diaobetol,2000,37:87-92.
  • 2孙子林,刘乃丰,王基平,刘必成.运用流动注射分析技术检测血清糖基化终产物-肽水平[J].中华内分泌代谢杂志,2000,16(4):250-253. 被引量：15
  • 3Brownlee M.Negative Consequences of Glycation.Metabolism,2000,49(2 Suppl 1):9-13.
  • 4Raina AK.Perry G,Nunomura A,et al.Histochemical and Imunocytochemical Approaches to the Study of oxidative stress.Clin Chem Lab Med,2000,38:93-97.

二级参考文献2

共引文献14

同被引文献17

  • 1曾爱萍,曾水清,程扬.转化生长因子β1对培养的人RPE细胞MMP和TIMP-1mRNA表达的影响[J].眼科新进展,2006,26(2):81-84. 被引量：8
  • 2王爱玲,朱秀安,曹安民.糖尿病视网膜病变细胞生物学研究进展[J].眼科研究,2006,24(1):96-98. 被引量：6
  • 3Cases A.Recent advances in nephrology:highlights from the 35th annual meeting of the American society of nephrology[J].Drugs Today (Barc),2002,38(12):797-805.
  • 4Degenhardt T P,Alderson N L,Arrington D D,et al.Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat[J].Kidney Int,2002,61(3):939-950.
  • 5Yamagishi S,Nakamura K,Matsui T.Advanced glycation end products(AGEs) and their receptor(RAGE)system in diabetic retinopathy[J].Curr Drug Discov Technol,2006,3(1):83-88.
  • 6Kowluru R A.Effect of advanced glycation end products on accelerated apoptosis of retinal capillary cells under in vitro conditions[J].Life Sci,2005,76(9):1051-1060.
  • 7Vaccaro O,Eberly L E,Neaton J D,et al.Impact of diabetes and previous myocardial infarction on long-term survival:25-year mortality follow-up of primary screenees of the Multiple Risk Factor Intervention Trial[J].Arch Intem Med,2004,164(13):1438-1443.
  • 8Barile G R,Pachydaki S I,Tari S R,et al.The RAGE axis in early diabetic retinopathy[J].Invest Ophthalmol Vis Sci,2005,46(8):2916-2924.
  • 9Metz T O,Alderson N L,Thorpe S R,et al.Pyridoxamine,an inhibitor of advanced glycation and lipoxidation reactions:a novel therapy for treatment of diabetic complications[J].Arch Biochem Biophys,2003,419(1):41-49.
  • 10Stitt A,Gardiner T A,Anderson N L,et al.The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes[J].Diabetes,2002,51(9):2826-2832.

引证文献2

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中国糖尿病杂志
2006年 第2期

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