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炎症性肠病发病机制的微生物因素 被引量:28

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摘要 炎症性肠病(IBD)的病因和发病机制尚不明确,肠道微生物与IBD发病关系密切,IBD患者肠道菌群存在失调,有证据表明,正常人群的肠黏膜免疫系统对肠道正常菌群存在耐受,而某些具有IBD遗传易感性人群的肠黏膜免疫系统对其肠道菌群失去耐受,肠道茵群参与了 IBD的发病.肠道细菌及其产物能刺激肠黏膜免疫系统,诱发这些具有IBD遗传易感性人群肠黏膜免疫系统功能紊乱,产生异常的免疫反应.不过,探究肠道细菌与IBD发病之间的关系,尚需要进一步的临床和实验研究.
作者 白爱平
出处 《世界华人消化杂志》 CAS 北大核心 2006年第7期645-649,共5页 World Chinese Journal of Digestology
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