细胞色素P450的多样性与介导抗性的研究

The Reserch of the Diversify and the MediatedResistant Mechanism of Cytochrome P450

细胞色素单加氧酶是一类广泛分布在生物体内的重要酶系,在生物体内广泛分布,CYP450参与多种外源性化合物的代谢,内源性物质的合成,在生物体起到十分重要的作用,对P450的研究已从最开始的功能与定位深入到了它的分子机制和多样性等的研究,就P450的多样性、介导抗性的机制和分离方法作一综述。

Cytochrome P450-dependent monooxygenase are a very important enzymatic system ,which has been found in all living organisms systems axamined,these monooxygenase are able metabolize a phenomenal number of endogenous and exogenous compounds ,It is play a important role in the living organisms,the research of the cytochrome P450 start from the founcation and orientate to the mechanism of the meloc, diversify Act, the paper is elaborating the above.