摘要
目的：观察阿替洛尔和美托洛尔静脉注射治疗急性心肌梗死的疗效及安全性。方法：48例急性心肌梗死患者随机分为阿替洛尔组（n=24）和美托洛尔组（n=24），分别静脉注射阿替洛尔和美托洛尔5～10mg，观察并比较患者用药后5min血压及心率下降、24hST段恢复及心肌酶下降情况。结果：急性心肌梗死患者在血压及心率下降、ST段恢复、心肌酶下降、不良反应诸方面，阿替洛尔组与美托洛尔组无显著性差异（P〉0．05）。结论：阿替洛尔与美托洛尔在治疗急性心肌梗死时疗效及不良反应相当，本药价廉，更适合国内市场。
Objective To compare the therapeutic effect with safety of atenolol and metoprolol in the treatment of patients with acute myocardial infarction. Methods Forty-eight patients with acute myocardial infarction were randomly divided into two groups, atenolol group （n=24） and metoprolol group （n=24）, receiving 5 to 10 mg of intravenous atenolol and metoprolol respectively. Blood pressure and heart rate were observed 5 minutes after drug administration and ST segment change and cardiac enzymes were measured 24 hours after drug administration. Results There were no significant differences between the two groups in the reduction of blood pressure and heart rate, ST segment regression and reduction of cardiac enzyme（P〉0.05）. Conclusion Atenolol is similar to metoprolol in therapeutic effect and safety in the treatment of the patients with acute myocardial infarction.
出处
《实用诊断与治疗杂志》
2006年第5期324-325,327,共3页
Journal of Practical Diagnosis and Therapy
