摘要
对糖尿病和肥胖病病因学研究的不断发展使许多单基因糖尿病和肥胖病被发现。对中国人已开展的青少年发病型成人糖尿病、线粒体糖尿病、黑皮素4受体(MC4R)及部分伴糖尿病的遗传综合征的研究提示,单基因肥胖病及糖尿病存在种族、遗传和临床特点的异质性。对这些特殊类型糖尿病和肥胖病的深入认识将有助于对疾病的病因细致分类和个体化治疗的指导。
With the development of genetic studies for diabetes and obesity, many monogenic diabetes and obesity genes have been identified. In Chinese, genetic scanning is performed for maturity-onset diabetes of the young, mitochondrial diabetes, Wolfram syndrome, severe obesity, and several mutations have been detected. Genetic heterogeneity has been found among Chinese and other population. These studies are very helpful to the etiological diagnosis and individual theraov for the soecifie types of diabetes and obesity.
出处
《国际内分泌代谢杂志》
2006年第3期145-148,共4页
International Journal of Endocrinology and Metabolism
