摘要
胰岛β细胞凋亡在糖尿病的发病中扮演重要角色,1、2型糖尿病β细胞凋亡的分子机制有所不同。在1型糖尿病中,胰岛β细胞主要通过死亡受体介导的信号转导途径及颗粒酶B途径发生凋亡,而在2型糖尿病中,线粒体途径是胰岛β细胞凋亡的主要信号转导途径。多种细胞因子通过激活核转录因子调节相应基因表达,进而调控胰岛β细胞的凋亡。
Islet beta-cell apoptosis plays an essential role in the onset of diabetes. The molecular mechanisms inducing apoptosis of beta-cells in type 1 and type 2 diabetes are different. In type 1 diabetes, signal transduction pathway mediated by death receptor and granzyme B pathway participate in the beta-cell apoptosis, however, the main transduction pathway leading to beta-cell apoptosis in type 2 diabetes is mitochondria pathway. Furthermore, many cytokines can regulate the related genes expression by activating nuclear factors, and then control apoptosis of beta-cell.
出处
《国际内分泌代谢杂志》
2006年第3期163-166,共4页
International Journal of Endocrinology and Metabolism
关键词
Β细胞
凋亡
分子机制
糖尿病
Beta-cell
Apoptosis
Molecular mechanism
Diabetes
