摘要
目的:探讨幽门螺杆菌感染与肺癌的相关性。方法:采用50例肺癌与50例非肿瘤病人分组对照研究模式,用ELSIA方法检测两组血清幽门螺杆菌IgG类抗体(Hp-IgG)和幽门螺杆菌细胞毒素相关蛋白IgG类抗体(Hp-CagA-IgG)的水平。结果:幽门螺杆菌IgG类抗体,肺癌组阳性46例(92.0%),对照组阳性22例(44.0%),P<0.01;肺癌组HP-IgG含量250.72±193.02,对照组HP-IgG含量70.10±21.62,P<0.01。幽门螺杆菌Hp-CagA-IgG,肺癌组阳性44例(88.0%),对照组阳性10例(20.0%),P<0.01。肺癌病人中,Hp-IgG含量,鳞癌明显高于腺癌和小细胞癌,P<0.05;但Hp-IgG及Hp-CagA-IgG阳性率,鳞癌、腺癌、小细胞癌三者之间无显著性差异,P>0.05。结论:肺癌与幽门螺杆菌感染密切相关,并且在不同病理类型中感染程度有区别。
Objectives:To analyze the correlation between H. pylori infection and lung cancer. Methods: We selected 50 patients with lung cancer and 50 individuals without tumor as control. The levels of H. pylori IgG and HP-CagA-IgG were detected with ELISA. Resuits:The positive rate of H.pylori IgG was significantly higher in the lung cancer group than that in the control group (92% (46) and 44% (22), P 〈0.01 ). Moreover, there was significant difference for the concentrations of serum H.pylofi IgG in the two groups (250.72 ± 193.02 vs.70.10 ± 21.62, P 〈 0.01 ). The positive rate of HP-CagA-IgG in the lung cancer group was 88% (44), but in the control group, it was 20% (10) ( P 〈 0.01 ). For the different pathologic types of lung cancer, the concentration of H.pylori IgG for squamous lung cancer was significantly higher than adenocarcinoma and small-cell lung cancer ( P 〈 0.05). However, there were not significant differences for the positive rates of H. pylori IgG and HP-CagA-IgG among the three pathologic types of lung cancer ( P 〉 0.05). Conclusions:There was a strong correlation between H. Pylori infection and lung cancer, and for the different pathologic types of lung cancer, the infections were different.
出处
《四川省卫生管理干部学院学报》
2006年第1期3-4,共2页
Journal of Sichuan Continuing Education College of Medical Sciences
关键词
肺癌
幽门螺杆菌
抗体
相关性
Lung cancer
Helicobacter pylofi
Antibody Correlation