肺癌患者血清幽门螺杆菌IgG类抗体检测

Detection of IgG Antibodies against Helicobacter Pybori in Patient with Lung Cancer

目的:探讨幽门螺杆菌感染与肺癌的相关性。方法:采用50例肺癌与50例非肿瘤病人分组对照研究模式,用ELSIA方法检测两组血清幽门螺杆菌IgG类抗体(Hp-IgG)和幽门螺杆菌细胞毒素相关蛋白IgG类抗体(Hp-CagA-IgG)的水平。结果:幽门螺杆菌IgG类抗体,肺癌组阳性46例(92.0%),对照组阳性22例(44.0%),P<0.01;肺癌组HP-IgG含量250.72±193.02,对照组HP-IgG含量70.10±21.62,P<0.01。幽门螺杆菌Hp-CagA-IgG,肺癌组阳性44例(88.0%),对照组阳性10例(20.0%),P<0.01。肺癌病人中,Hp-IgG含量,鳞癌明显高于腺癌和小细胞癌,P<0.05;但Hp-IgG及Hp-CagA-IgG阳性率,鳞癌、腺癌、小细胞癌三者之间无显著性差异,P>0.05。结论:肺癌与幽门螺杆菌感染密切相关,并且在不同病理类型中感染程度有区别。

Objectives：To analyze the correlation between H. pylori infection and lung cancer. Methods： We selected 50 patients with lung cancer and 50 individuals without tumor as control. The levels of H. pylori IgG and HP-CagA-IgG were detected with ELISA. Resuits：The positive rate of H.pylori IgG was significantly higher in the lung cancer group than that in the control group （92% （46） and 44% （22）, P 〈0.01 ）. Moreover, there was significant difference for the concentrations of serum H.pylofi IgG in the two groups （250.72 ± 193.02 vs.70.10 ± 21.62, P 〈 0.01 ）. The positive rate of HP-CagA-IgG in the lung cancer group was 88% （44）, but in the control group, it was 20% （10） （ P 〈 0.01 ）. For the different pathologic types of lung cancer, the concentration of H.pylori IgG for squamous lung cancer was significantly higher than adenocarcinoma and small-cell lung cancer （ P 〈 0.05）. However, there were not significant differences for the positive rates of H. pylori IgG and HP-CagA-IgG among the three pathologic types of lung cancer （ P 〉 0.05）. Conclusions：There was a strong correlation between H. Pylori infection and lung cancer, and for the different pathologic types of lung cancer, the infections were different.