动脉粥样硬化发病过程与腺苷三磷酸结合盒转运体A1和肝X受体的作用

Adenosine triphosphate binding cassette transporter A1 and Liver X-activated receptors in atherosclerosis

目的:分析腺苷三磷酸结合盒转运体A1和肝X受体与动脉粥样硬化的关系。资料来源:分别以“ABCA1”和“LXR”为检索词,应用计算机在Medline、中文全文数据库CNKI、维普数据库检索2000-01/2005-09期间相关文章。手工检索近期相关文献及书籍。资料选择:对资料进行初审,选出相关文献,筛除无关文献。纳入标准:①与腺苷三磷酸结合盒转运体A1、肝X受体结构功能有关的文献。②腺苷三磷酸结合盒转运体A1、肝X受体与血脂关系的文献。③腺苷三磷酸结合盒转运体A1、肝X受体多态或突变与血脂关系的文献。④腺苷三磷酸结合盒转运体A1、肝X受体与冠状动脉粥样硬化性心脏病、心肌梗死、脑梗死、动脉粥样硬化相关的文献。⑤腺苷三磷酸结合盒转运体A1、肝X受体多态或突变与冠状动脉粥样硬化性心脏病、心肌梗死、脑梗死、动脉粥样硬化相关的文献。排出标准:①相关文献中内容相似的文献。②与纳入标准不符的文献。资料提炼:共找出相关文献86篇,并查找全文。选取4篇涉及腺苷三磷酸结合盒转运体A1、肝X受体的结构功能等基础内容;21篇涉及腺苷三磷酸结合盒转运体A1、肝X受体与血脂代谢相关的内容;11篇涉及腺苷三磷酸结合盒转运体A1、肝X受体与动脉粥样硬化相关的内容;4篇涉及肝X受体对腺苷三磷酸结合盒转运体A1调节的内容;2篇与脑卒中有关的内容。共收入42篇文献,其中21篇列为参考文献。资料综合:分析了腺苷三磷酸结合盒转运体A1、肝X受体的结构和功能的基本情况;文献显示腺苷三磷酸结合盒转运体A1和肝X受体对血脂谱有不同程度的调节;肝X受体对腺苷三磷酸结合盒转运体A1的表达也有调节;两者可能是通过影响血脂谱,或者其他途径对动脉粥样硬化有一定作用。结论:腺苷三磷酸结合盒转运体A1与肝X受体可能通过调节血脂谱在动脉粥样硬化发病过程中起重要的作用,而且腺苷三磷酸结合盒转运体A1的表达可能受肝X受体的调控,因此它们可能是与动脉粥样硬化密切相关的心脑血管疾病的重要候选基因。

OBJECTIVE： To explore the relation of adenosine triphosphate binding cassette transporter A1 （ABCA1） and Liver X-activated receptors （LXRs） to atherosclerosis （AS）. DATA SOURCES： Using the terms of ＂ABCA1 and LXRs＂, a computer search of Medline database was undertaken to identify the articles published in English between January 2000 and September 2005. We also retrieved the Chinese Full-Text database and Vip Information database for related Chinese articles published from January 2000 to September 2005 with the same keywords. Meanwhile, we searched manually recent published literatures and magazines. STUDY SELECTION： The data were selected firstly to choose the relevant articles. Inclusive criteria： ①Articles about the structure and function of ABCA1 and LXRs. ②Articles about the relation of ABCA1 and LXRs to blood lipids. ③Literatures about the relation of polymorphism and mutation of ABCA1 and LXRs with blood lipids. ④Literatures on correlation of ABCA1 and LXRs to coronary atherosclerotic heart disease （CAHD）, myocardial infarction （MI）, cerebral infarction （CI） and AS. ⑤Related literatures on relation of polymorphism and mutation of ABCA1, LXRs with CAHD, MI, CI and AS. The repeated and not met the inclusive criteria articles were excluded. DATA EXTRACTION： Totally 42 articles from 86 ones were selected and full texts were searched, including 4 ones related to the structure and function of ABCA1 and LXRs; 21 ones about the relation of ABCA1 and LXRs with blood lipids metabolism; 11 ones about the relation between ABCA1, LXRs and AS; 4 ones related to the modulation of LXRs to ABCA1 and 2 ones related to stroke. There were 21 articles as the references. DATA SYNTHESIS： All articles were reviewed to analyze the structure and function of ABCA1 and LXRs. The articles suggested that ABCA1 and LXRs could modulate blood lipids spectrum at different levels and LXRs could modulate ABCA1, which affected AS by influencing the blood lipids spectrum. CONCLUSION： ABCA1 and LXRs play important roles in pathogenic process of AS by modulating blood lipids metabolism, and LXRs can modulate the expression of ABCA1, which may be the important candidate genes for cerebro-cardiovascular diseases closely correlated with AS.