卵巢癌术后复发的特征及相关影响因素分析

Characters and related factors of postoperative recurrence of ovarian carcinoma

目的 探讨卵巢癌术后复发的特征及相关因素，寻找预防和降低卵巢癌复发的方法。方法 回顾性分析83例卵巢癌患者的临床病理资料，对其中复发的34例进行分析，寻找复发的相关因素。结果 完全缓解的79例中，复发34例，1年内复发率最高，为61．8％；复发部位盆腔最多，占61．8％。Ⅰ、Ⅱ期复发率较Ⅲ、Ⅳ期低（P〈0．005）；浆液性癌复发率较粘液性癌及其他癌高（P〈0．025）。组织低、中分化较高分化复发率高（P〈0．005）。残余病灶直径〈2cm，较≥2cm者复发率低（P〈0．005）。术后化疗0。5个疗程，较≥6个疗程者复发率高（P〈0．05）。有无大网膜转移者以及原发灶部位为单侧及双侧卵巢者之间复发率差异均无显著性（P〉0．05）。结论 卵巢癌术后1年内复发率最高；最常见复发转移部位为盆腔。复发与临床期别、病理类型、组织分化、规范肿瘤细胞减灭术及术后残余病灶的大小及术后规范化疗有关。

Objective To analyze the characters and potential factors of postoperative recurrence of ovarian carcinoma. To investigate the methods of preventing and reducing the recurrence of ovarian carcinoma. Methods The clinic - pathological features of 83 patients with ovarian carcinoma, including 34 with recurrence were analyzed retrospectively. Results Among the 79 cases achieved complete remission, 34 reeun＇ed. The recurrent rate was highest within 1 year, 61.8%, and the most cornmen recurrent sites are within pelvic, 61.8%. The recurrent rate of FIGO stage Ⅰ-Ⅱ was significantly lower than that of stage Ⅲ-Ⅳ （ P 〈 0.005）. The recurrent rate of serous carcinoma was higher than that of mucous or other s. the recurrent rate of poor or moder ate differentiated cancer was significantly higher than that of well differentiated （ P 〈 0.05）. In cases with 〈 2 em residue, the recurrent rate was significantly lower than those with≥2 cm residue （ P 〈0.005）. Compared with the patient treated with≥6 chemotherapy cycles the recurrent rate of the patients with 1 - 5 chemotherapy cycles was higher （ P 〈 0.05）. No significant difference of recurrence was observed between the patients with omental metastasis and without （ P 〉 0.05）, unilateral primary tumor and bilateral （ P 〉 0.05）. Conclusions Ovarian carcinoma mostly recur within 1 year and at pelvic. The recurrence is associated with clinical stage, histological differentiation, postoperative residual size and courses of regular chemotherapy.