黄芪对哮喘患者气道反应性的影响

Effect of Radix Astragali on airway reactivity of asthmatics

目的:探讨黄芪注射液降低气道反应性的作用.方法:哮喘患者32例,治疗前测定用力肺活量(FVC)、第1秒用力呼气量(FEV1)、FEV1占预计值的百分率(FEV1%)、最大呼气流速(PEF),用乙酰甲胆碱(Mch)累积量0.033μmol和1.98μmol作激发试验.经黄芪注射液治疗3wk后,再测定上述肺功能指标.结果:黄芪注射液治疗后患者FVC增加(3.42±0.22→3.53±0.22,P<0.05);FEV1(2.32±0.13→2.56±0.13),FEV1%(76.6±2.8→85.3±3.9)和PEF(3.80±0.17→4.20±0.17)的增加更有显著性意义(P<0.01).结论:黄芪能改善哮喘患者的通气功能,降低气道高反应性.

AIM： To study the effect of Radix Astragali injection on the airway reactivity. METHODS： Thirty-two cases of asthmatic patients receiving Radix Astragali injection were subjected to the study. FVC, FEV1, FEV1 % and PEF were measured before and after treatment. Methacholine provocation tests with 0. 033μmol and 1.98 μmol were conducted. RESULTS： After 32 asthmatic patients received the treatment of Radix Astragali injection, FVC（3.42±0. 22→3.53±0.22, P〈0.05）, FEV1（2.32±0.13→2.56±0.13）, FEV1% （76.6±2.8→85.3±3.9） and PEF （ 3.80±0.17→4.20±0.17 ） were significantly increased （P〈0.01）. CONCLUSION： Radix Astragali injection can improve the ventilation function and suppress the airway reactivity of asthmatic patients.