外胚叶发育不全基因信号途径与汗腺发育及修复的关系

RELATIONSHIP OF ECTODYSPLASIN GENE SIGNALING WITH DEVELOPMENT AND REGENERATION OF SWEAT GLANDS

目的探讨外胚叶发育不全(ectodysplasin,EDA)基因信号途径与汗腺发育及修复的关系。方法通过对近期国内外相关文献的回顾,了解EDA基因的生物学特性、信号传导途径和促进汗腺发育的分子机制。结果大量实验证实EDA基因在胎儿发育早期参与了胚胎皮肤汗腺的形态和功能发生。结论EDA基因对皮肤汗腺的发生和结构的形成以及皮肤生理功能的维持具有重要意义,可为实现基因调控皮肤受损汗腺的完美修复找到一条新路。

Objective To investigate the expression of ectodysplasin （EDA） gene signaling and its relationship with the development and regeneration of sweat glands, Methods The articles concerned in the latest years were extensively reviewed. Results EDA gene is an important signaling pathway associated with the developmental procedure of sweat glands in early fetal stage. Abnormality or depletion of function in sweat glands partially owed to the defect of EDA gene. Conclusion EDA signaling has its biological significance in inducing development and morphogenesis of sweat glands and in maintaining physiological function of skin. It could be a new approach to repair or regenerate the sweat glands for clinical therapy by regulating the expression of EDA gene.