摘要
瞄准:与溃疡的 culitis (UC ) 并且与健康控制题目相比在成年病人决定血浆肉毒碱酉旨侧面。方法:用 ESI 三倍的四极双人脚踏车团分光术,肉毒碱酉旨侧面与 UC 和 44 匹配年龄、匹配性的健康控制在 44 个病人被测量。结果:在免费肉毒碱与 UC 和健康控制在病人之间铺平的 fasting 没有有效差量。禁食 propionyl-(0.331 +/- 0.019 对 0.392 +/- 0.017 micromol/L ) , butyryl-(0.219 +/- 0.014 对 0.265 +/- 0.012 ) ,并且 isovalerylcarnitine (0.111 +/- 0.008 对 0.134 +/- 0.008 ) 层次在 UC 病人被减少。由对比,octanoyl-的水平( 0.147 +/- 0.009 对 0.114 +/- 0.008 ),decanoyl-( 0.180 +/- 0.012 对 0.137 +/- 0.008 ),myristoyl-( 0.048 +/- 0.003 对 0.039 +/- 0.003 ),palmitoyl-( 0.128 +/- 0.006 对 0.109 +/- 0.004 ),palmitoleyl-( 0.042 +/- 0.003 对 0.031 +/- 0.002 )并且 oleylcarnitine ( 0.183 +/- 0.007 对 0.163 +/- 0.007 ;P 【
0.05 在所有比较) 与 UC 在病人被增加。结论:我们的数据在 UC 病人建议肉毒碱酉旨的选择参与,可能由于他们的改变的新陈代谢。
AIM: To determine the plasma carnitine ester profile in adult patients with ulcerative culitis (UC) and compared with healthy control subjects. METHOD: Using ESI triple quadrupole tandem mass spectrometry, the carnitine ester profile was measured in 44 patients with UC and 44 age- and sex-matched healthy controls. RESULTS: There was no significant difference in the fasting free carnitine level between the patients with UC and the healthy controls. The fasting propionyl- (0.331 ± 0.019 vs 0.392 ± 0.017 μmol/L), butyryl- (0.219 ± 0.014 vs 0.265 ± 0.012), and isovalerylcarniUne (0.111 ± 0.008 vs 0.134 ± 0.008) levels were decreased in the UC patients. By contrast, the level of octanoyl- (0.147 ± 0.009 vs 0.114 ± 0.008), decanoyl- (0.180 ± 0.012 vs 0.137 ± 0.008), myristoyl- (0.048 ± 0.003 vs 0.039 ± 0.003), palmitoyl- (0.128 ± 0.006 vs 0.109 ± 0.004), palmitoleyl- (0.042±0.003 vs 0.031 ± 0.002) and oleylcarnitine (0.183 ± 0.007 vs 0.163 ± 0.007; P 〈 0.05 in all comparisons) were increased in the patients with UC. CONCLUSION: Our data suggest selective involvement of the carnitine esters in UC patients, probably due to their altered metabolism.
基金
Supported by the grant of Ministry of Health,No.ETT 325/2003 and 595/2003
the grant of Hungarian Science Foundation,No.OTKA T 35026 and T 49589
from the National grant No.NKFP-4/005/2002