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人骨肉瘤组织中livin的表达 被引量：3

Expression of livin in human osteosarcoma
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摘要 目的：研究livin在骨肉瘤中的表达及其临床意义。方法：对60例骨肉瘤患者的临床病理资料进行回顾性分析。应用livin的抗体对上述患者的肿瘤组织切片进行免疫组织化学染色并进行统计学分析。结果：60例标本中32例为阳性，总阳性率为53．3％。livin的表达与患者年龄、性别、骨肉瘤亚型无明显关系。但与Ermeking外科分期有关，Ⅰ～ⅡA期与ⅡB～Ⅲ期之间，肿瘤livin表达率差异明显（P〈0．05）。结论：livin在骨肉瘤组织中有较高比例的表达，livin可作为预测骨肉瘤预后的重要指标。 Objective ：To investigate the expression of livin in osteosarcoma. Methods： The clinic pathologic information of sixty cases of osteosarcoma was studied retrospectively. Anti - livin polyclonal antibody was used in immunohistochemical staining. Results： The expression rate of livin protein in osteosarcoma was 53.3% （32/60）. The expression of livin was correlated with Ermeking surgical staging. Its expression rate in Enneking surgical staging Ⅰ - Ⅱ A was significantly lower than that in staging Ⅱ B - Ⅲ （P 〈0.05）. The expression was not correlated with the pathological subtypes of osteosarcoma. Conclusion： A high expression of livin was found in osteosarcoma tissue. Livin can be used as an important index for predicting prognostic conditions of human osteosarcoma.
作者 张勇 杨彤涛 李存孝 范清宇 马保安
机构地区 第四军医大学第二附属医院全军骨科中心
出处 《现代肿瘤医学》 CAS 2006年第5期605-607,共3页 Journal of Modern Oncology
关键词 骨肉瘤 LIVIN 免疫组织化学 表达 osteosarcoma livin immunohistochemistry
分类号 R738.1 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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二级参考文献4

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共引文献7

同被引文献17

  • 1李日恒,宋燕,张海山,郭阳,孟子辉,赵涛,汲崇德.新发现的Livin基因在结直肠癌组织中mRNA表达及其临床意义[J].中国实验诊断学,2006,10(12):1406-1408. 被引量：4
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引证文献3

二级引证文献7

现代肿瘤医学
2006年 第5期

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