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Pin1、β-catenin与人类肿瘤 被引量:2

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摘要 Pin1是高度保守的、特异的磷酸化异构酶,它作用于蛋白质序列中磷酸化的丝氨酸/苏氨酸-脯氨酰键,使底物异构化,由顺式变为反式,调节底物功能。Pin1在人类恶性肿瘤的发生发展过程中占有重要的地位。β-catenin是一种致癌基因转录激活因子,β-catenin的异常蓄积使其下游的靶基因表达上调,促进细胞的恶性转化和肿瘤的产生。
出处 《现代肿瘤医学》 CAS 2006年第5期616-618,共3页 Journal of Modern Oncology
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参考文献26

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二级参考文献41

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  • 4Wintjens R, Wieruszeski JM, Drobecq H, et al. 1H NMR study on the binding of Pinl Trp-Trp domain with phosphothreonine peptides[J]. Biol Chem, 2001, 276(27):25150-25156.
  • 5Crenshaw DG, Yang J, Means AR, et al. The mitotic peptidylpmlyl isomerase, Pinl, interacts with Cdc25 and Plx1 [ J]. EMBO J, 1998, 17(5):1315-1327.
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  • 8Yaffe MB, Schutkowski M, Shen M, et al. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitoticre gulatory mechanism [ J]. Science, 1997, 278 ( 5345 ) : 1957-1960.
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  • 10Zhou XZ, Kops O, Wemer A, et al. Pinl-dependent pmlyl isomerization regulates dephosphorylation of Cdc25C and tan proteins[J]. Mol Cell,2000, 6(4) :873-883.

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