期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

新型抑癌基因RASSF1与胃癌的关系 被引量：1

The relationship between new suppressor gene RASSF1 and gastric-carcinoma
下载PDF
导出
摘要 新近发现的RASSF1A基因位于染色体3p21.3区,是一种新型侯选肿瘤抑制基因,多项研究表明它可参与细胞凋亡和多种恶性肿瘤的发生。在多种肿瘤中失活。该基因的失活与其启动子区甲基化和杂合子缺失有关。另外发现一些病毒的感染可影响其甲基化状态。 RASSF1 , a putative tumor suppressor gene identified at 3p21.3 has been frequently observed. Many reports suggested that those was no RASSF1 expression or was at abnormally low level in many carcinomas. It is possible that aberrant DNA methylation and loss of heterozygusity might be involved in the loss of RASSF1 expression. Other results demonstrate a relationship between EBV infection and aberrant methylatiun.
作者 李学彦 傅宝玉
机构地区 沈阳军区总医院肿瘤科 中国医科大学附属一院消化科
出处 《中国癌症杂志》 CAS CSCD 2006年第5期396-398,共3页 China Oncology
关键词 RASSF1A 甲基化 胃癌 抑癌基因 RASSF1 A methylatiun gastric-carcinoma suppressor gene
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献20

  • 1Lerman MI,Minna JD.The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3:identification and evaluation of the resident candidate tumor suppressor genes[J].Cancer Res,2000,60(21):6116-6133.
  • 2Dammann R,Li C,Yoon JH,et al.Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3 p21.3[J].Nat Gene,2000,25 (3):315-319.
  • 3Tommasi S,Dammann R,Jin SG,et al.RASSF3 and NORE1:iaentification and cloning of two human homologues of the putative tumor suppressor gene RASSF1[J].Oncogene,2002,21 (17):2713 -2720.
  • 4Vos MD,Ellis CA,Bell A,et al.Ras use the novel tumor suppressor RASSF1 as an effector to mediate apoptosis[J].Biol Chem,2000,275(46):35669-35672.
  • 5Agathanggelou A,Honorio S,Macartney DP,et al.Methylation associated inactivation of RASSF1A from region 3p21.3 in lung,breast and ovarian tumours[J].Oncogene,2001,20 (12):1509-1518.
  • 6Burbee D,Forgacs E,Zochbauer-Muller S,et al.The RASSF1A locus in the 3p21.3 homozygous deletion region:epigenetic inactivation in lung and breast cancer and suppression of malignant phenotype[J].Natl Cancer Inst,2001,93 (9):691-699.
  • 7Dammann R,Takahashi T.Pfeifer GP et al.The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas[J].Oncogene,2001,20(27):3563-3567.
  • 8Baylin SB,Herman JG.DNA hypermethylation in tumorigenesis:epigenetics joins genetics[J].Trends Genet,2000,16 (4):168-174.
  • 9Paulsen M,Ferguson-Smith AC.DNA methylation in genomic imprinting,development,and disease[J].Pathol,2001,195(1):97-110.
  • 10Yu MY,Tong JH,Chan PK,et al.Hypermethylation of the tumor suppressor gene RASSF1A and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers[J].Int J Cancer,2003,105 (2):204 -209.

同被引文献11

  • 1HORIGUCHI K,TOMIZAWA Y,TOSAKA M,et al.Epigenetic inactivation of RASSF1A candidate tumor suppressor gene at 3p21.3 in brain tumors[J].Oncogene,2003,22 (49):7862-7865.
  • 2HESSON L,BIECHE I,KREX D,et al.Frequent epigenetic inactivation of RASSFIA and BLU genes located within the critical 3p21.3 region in gliomas[J].Oncogene,2004,23(13):2408-2419.
  • 3DAMMANN RoLI C,YOON JH,et al.Epigenetic inactivation of a RAS association domain family protein from the lung turnout suppressor locus 3p21.3[J].Nat Gene,2000,25(3):315-319.
  • 4PFEIFER GP,YOON JH,LIU L,et al.Methylation of the RASSF1A genes in human cancers[J].Biol Chem,2002,383 (5):907-914.
  • 5LERMAN MI,MINNA JD.The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3:identification and evaluation of the resident candidate tumor suppressor genes.[J].Cancer Res,2000,60(21):6116-6133.
  • 6HAMILTON DW,LUSHER ME,LINDSEY JC,et al.Epigenetic inac-tivation of the RASSFIA tumout suppressor gene in ependymoma[J].Cancer Lett,2005,227(1):75-81.
  • 7HESSON LB,COOPER WN,LATIF F.The role of RASSF1A hypermethylation in cancer[J].Dis Markers,2007,23 (1-2):73-87.
  • 8GAO Y,GUAN M,SU B,et al.Hypermethylation of the RASSF1A gene in glionmas[J].Clin Chim Acta,2004,349 (1-2):173-179.
  • 9LUSHER ME,LINDSEY JC,LATIF F,et al.Biallelic Epigenetic inactivation of the RASSF1A tumour suppressor gene in medul-loblastoma[J].Cancer Res,2002,62(20):5906-5911.
  • 10LINDSEY JC,ANDERTON JA,LUSHER ME,et al.Epigenetic events in medulloblastoma development[J].Neurosurg Focus,2005,19(5):E10.

引证文献1

中国癌症杂志
2006年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部