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脊髓缺血再灌注损伤中运动诱发电位的变化及其监测作用 被引量：1

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摘要 目的探讨缺血再灌注损伤脊髓运动诱发电位(MEP)的变化规律及其对神经功能的监测作用。方法40只新西兰大白兔随机分为假手术组、缺血15min、30min、45min、60min组,每组8只。采用肾下腹主动脉阻断法,建立脊髓缺血再灌注模型。对各组在缺血前、缺血期间、再灌注期间MEP变化进行监测。术后采用Reuters法对后肢感觉和运动反射功能评分,再灌注48h Jacobs法对后肢运动功能分级。结果缺血后MEP潜伏期和波幅分别逐渐延长及减少,缺血15min时MEP波形消失,再灌注15min时MEP波形恢复,但潜伏期大于缺血前,波幅小于缺血前。开放腹主动脉后,各组MEP潜伏期和Reuter评分值总体变化趋势为缺血60min组>缺血45min组>缺血30min组>缺血15min组>假手术组,MEP波幅总体变化趋势为假手术组>缺血15min组>缺血30min组>缺血45min组>缺血60min组。再灌注48h后肢运动功能评分分值总体变化趋势为假手术组>缺血15min组>缺血30min组>缺血45min组>缺血60min组。结论脊髓缺血时间越长,再灌注后MEP恢复越慢,后肢运动障碍越明显,监测MEP能够准确地反映脊髓缺血再灌注损伤的有无和程度的轻重。
作者 方华 王泉云 李昌熙 江从勋
机构地区 四川大学华西医院 四川大学基础医学与法医学院
出处 《四川医学》 CAS 2006年第5期455-457,共3页 Sichuan Medical Journal
关键词 脊髓保护 缺血 再灌注损伤 诱发电位
分类号 R363 [医药卫生—病理学]
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参考文献10

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同被引文献12

  • 1孟斌,杨惠林.低温对脊髓缺血再灌注损伤的治疗作用[J].脊柱外科杂志,2003,1(4):234-236. 被引量：1
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引证文献1

二级引证文献1

四川医学
2006年 第5期

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