透明质酸钠治疗退行性膝关节炎的临床观察

Clinical Study on Sodium Hyaluronatte Intra-articular Injection in Treatment of Degenerative Osteoarthritis of Knee

目的观察透明质酸钠注射液对退行性膝关节炎(DOA)治疗作用。方法60例共78膝关节腔内注入透明质酸钠注射液2m l,每周给药1次共3-5次。观察治疗前后关节疼痛、肿胀等症状的缓解,以及关节活动度、步行能力、上下楼梯、下蹲和跑步等关节功能的改善情况。结果56例78膝关节获得1月-1年随访,显效45例(占57.7%),有效19例(占24.3%),进步2例(占9%),无效2例(占9%),总有效率82%,未见明显副作用。结论透明质酸钠注射液关节腔内注射治疗膝关节疾病具有很好的治疗作用。

Objective To evaluate the clinical effect of sodium hyaluronate（SH） intra-articular injection in treatment of degenerative osteoarthritis（DOA） of knees. Methods Sixty patients （78 knees） suffered from DOA were treated by SH injection intra-articularly three to five times once a week. According to Lysholm scoring, clinical signs such as pain, swelling, range of movement, and the ability of walking, going upstairs and downstairs, squatting, running, were assessed before and after treatment. Results 56 cases were followed up for 1 to 12 months., There were obvious improvements in the signs and function of knees in 45 patients （57.7 % ） , only some improvements in 19 patients（24. 3 % ） ,and no obvious improvements in other 2 patients（9 % ）. The total effectiveness rate was 82 %. No toxic or side effect was observed. Conclusion Intra-articular injection of SH has a positive effect in relief of clinical symptoms and improvement of articular function of DOA of knee.