肝活检对无症状HBV携带者的临床意义

Clinical Significance of Liver Biopsy for Asymptomatic HBV Carriers

目的探讨肝活检组织学对无症状HBV携带者(AsC)的临床意义。方法共166例无症状HBV携带者接受快速经皮肝穿刺,全部病例血清HBsAg均为阳性,肝功正常,病程超过6个月。结果所有患者肝组织学显示肝内均有不同程度的炎症及纤维化。结论肝活检可作为判断肝病活动性、纤维化程度和抗病毒治疗的根据。在转氨酶正常的病例,推行肝活检有助于拟定合理的治疗方案。

Objective The aim of this study was to investigate clinical significance of liver biopsy for asymptomatic HBV carriers. Methods A total of 166 HBsAg positive asymptomatic HBV carriers performed percutaneously liver biopsy. Results None of patients had norreal liver pathology. Conclusion Liver biopsy in cases of chronic HBV infection is helpful to assess accurately both the current activity of the disease and the degree of fibrosis and to estimate if anti-viral therapy should be conducted . It seems useful to make a rational plan to treat chronic hepatitis B patients with normal transaminases.