冰片注射液对实验性脑缺血的保护作用

The protective effect of Borneol on experimental cerebral ischemia

目的研究冰片注射液对实验性脑缺血的保护作用及机制。方法分别采用小鼠不完全脑缺血模型、KCN致小鼠急性脑缺血模型及大鼠MCAO模型,观察小鼠不完全脑缺血后的脑卒中指数、KCN致小鼠急性脑缺血后的翻正反射消失时间及MCAO缺血再灌大鼠脑组织内MDA含量、SOD及LDH酶活力。结果冰片注射液可降低不完全脑缺血小鼠的脑指数,缩短KCN致小鼠急性脑缺血后的存活时间,降低MCAO大鼠脑组织内MDA含量、提高SOD及LDH酶的活力。结论冰片注射液对实验性脑缺血具有保护作用。

Objective To investigate the protective effect of Borneol on experimental cerebral ischemia and its mechanism. Method Three cerebral ischemia animal models were used to study the effect of Borneol on them. Results Borneol could significantly cut down the stroke index score of mice induced by local cerebral ischemia, prolong the survival time caused by KCN and decrease the content of MDA, and increase the activities of LDH and SODase in the brain tissue after 3h of cerebral ischemia and 3h of repeffusion. Conclusion Borneol has the effect on experimental cerebral ischemia.