乌司他丁在肺挫伤治疗中的作用

Therapeutic Value of Ulinastatin in Pulmonary Contusion

目的:研究乌司他丁(UTI)对肺挫伤的治疗作用。方法:选择68例肺挫伤患者,随机分为UTI治疗组(n=34)和常规治疗组(对照组,n=34),对照组接受常规治疗,UTI治疗组在常规治疗基础上静脉滴注乌司他丁20万U,8h1次,连用 6d。观察两组的临床疗效并检测治疗前及治疗第4天、第7天的血清TNF-α、IL-6水平变化。结果:UTI治疗组与对照组在治疗前TNF-α、IL-6水平无差异。治疗后UTI治疗组的TNF-α、IL-6水平下降较对照组明显(P<0．05)。UTI治疗组中ARDS的发生率明显低于对照组(P<0．05)。结论:乌司他丁可显著抑制机体炎症介质的产生,阻断肺挫伤向ARDS 进展。

Objective：To observe the therapeutic value of Ulinastatin in Pulmonary Contusion by comparison between Ulinastatin group and no Ulinastatin group（routine treatment group）. Methods： 68 pulmonay contusion patients were randomly divided into routine treatment group （n=34）and Ulinastatin treatment group （n=34）. Both groups were given routine treatment, while the patients of the Ulinastatin treatment group were given Ulinastatin （200ku intravenously drip,once every 8 hours, and continued for 6 days）in addition. The efficacy of the therapy in both groups were assessed and serum TNF-α、IL-6 levels were measured on admission and on the fourth and seventh day in both groups. Results：The SIRS markers were not different both in Ulinastatin group and routine treatment group before treatment. TNF-α and IL-6 levels reduced more significantly after treatment in Ulinastatin group than routine group （p〈0. 05）. The Incidence of ARDS was lower in Ulinastatin treatment group than that in routine treatment group （p〈0. 05）. Conchtsion： Ulinastatin significantly inhibits the production of inflammatory cytokinases,and effectively prevent PC to proceed to ARDS.