心理应激对不同行为类型大学生血浆TXB_2及6-Keto-PGF_(1a)的影响

Effect of Psychological Stress on the Change of TXB_2 and 6-Keto-PGF_(1a) in College Students with Different Behavior Pattern

目的探讨急性心理应激对不同行为类型人群的血浆血栓素B2(TXB2)及6-酮-前列腺素(6-keto-PGF1a)的影响。方法用A型行为问卷(TABP)对150名大学生自愿者进行测试,筛选出A型行为和B型行为组各24名,再对A型行为和B型行为组随机分为应激组和对照组;应激后用放射免疫法测定其血浆中TXB2及6-Keto-PGF1a的含量。结果心理应激后,实验组及A、B型行为实验组血浆TXB2浓度均升高,与对照组相比差异有显著性(P<0.05);实验组及A、B型行为实验组血浆6-keto-PGF1a浓度均有变化,但差异均无显著性(P>0.05);实验组及B型行为实验组TXB2/6-Keto-PGF1a的比值都明显变大,差异均有显著性(P<0.05)。结论1急性心理应激可导致大学生血浆TXB2升高,TXB2/6-Keto-PGF1a的比值变大,提示应激可能是引起心血管功能改变的关键因素之一;2心理应激对不同行为大学生血浆TXB2及6-Keto-PGF1a浓度的影响不同,该结果可能是揭示特定人格好发心脑血管疾病的机制之一。

Objective To explore the effects of acute psychological stress on TXB2 and 6-Keto-PGF1a in college students with different behavior pattern. Methods 150 college volunteers were tested by using Type A Behavior Questionnaire. Type A behavior group and Type B behavior group with 24 members each were chosen among them, and the two groups were randomly divided into psychological stress group and control group. The concentration of Thromboxane B2 and 6- Keto- prostaglandin F1 alpha were assayed by using radioimmunity after psychological stress. Results The concentration of plasma Thromboxane B2 in stress group and Type A and B behavior stress group were increased after stress, compared with the contrast group, which showed significant difference within groups（P〈0. 05）. The concentration of plasma 6-Keto-PGF1, in stress group and Type A and B stress group changed after stress , but there was no significant difference among the groups. The ratio of TX B2/6-Keto-PGF1a, in stress group and Type B stress group were highly increased and suggested significant difference within groups（P〈0. 05）. Conclusion ①Acute psychological stress can lead to the increase of the concentration of Thromboxane B2 and 6-Ketoprostaglandin Fl alpha and the ration of TX B2/6-Keto-PGF1a ,it shows that the stress is one of the important factors which can cause the function change of blood vessel and homeostasis. ②The psychological stress brings different influence on the concentration of Thromboxane B2 and 6- Ketoprostaglandin Fl alpha in different Type behavior in college students. This findings may reveal that unusual behavior personality is one of the factors, which results in cardiovascular disease and cerebrovascular disease.