含益肺止咳胶囊化疗方案治疗耐药肺结核疗效观察

Clinical observation on the Therapeutic Effects of the Chemotherapy Combined with the use of yifeizhike Capsules on Drug-tolerant Tuberculosis

目的观察和评价含益肺止咳胶囊化疗方案对耐药肺结核的疗效。方法将68例耐药肺结核患者随机分为治疗组(A组、34例)和对照组(B组、34例)。治疗组应用益肺止咳胶囊联合抗结核化学药物持续治疗1年。对照组只用抗结核化学药物。两组抗结核药物组成相同。结果疗程结束时,痰菌阴转率A组73.5%,B组64.7%,A组显著高于B组(P<0.05);疗程结束时,病灶改变情况A组73.5%,B组61.7%,A组显著高于B组(P<0.05);不良反应发生率A组23.6%,B组50%,A组显低于B组(P<0.05)。结论含益肺止咳胶囊联合抗结核化学药物治疗耐药肺结核的疗效优于单纯抗结核化学药物化疗方案,且可减轻抗结核化学药物的不良反应。取得较好的疗效。

Objective To determine the therapeutic effects of the chemotherapy combined with the use of yifeizhike capsules on drug-tolerant tuber culosis. Methods 68 cases of drug-resistant tuber crlosis were randomly divided into Group A （the treatment group） amd Group B （the contrast group）. Group B were treated with antitubercrlotic chemotherapy only, Whil Group A were treated with yifeizhike capsules in addition to the chemotherapy used in Group B. Results At the end of the course of treatment, the rate of negative transfer of sputum tubercl bacillus in Group A （73. 5%） were found much higher than in Group B （64.7%） （P〈0.05）, and meanwhile, 73.5% of the foli and cavities in Group were improved, while cnly 61.7% in Group B （p〈0. 05）. The rate of side effects was 23.6% in Group A, whie 50% in Group B （p〈0. 05）. Conclusion The combined use of yifeizhike capsules and the traditional. Antituberculotic therapy can produce betler therapeutic effects on Drug-tolerant tuberculosis than the use of the traditional one only.