7'-O-菊酰基井冈羟胺A的合成

Synthesis of 7'-O-chrysanthemyl validoxylamine A

将拟除虫菊酸酰化后,与井冈霉素A的水解产物井冈羟胺A反应,合成了3个未见报道的7'-O-菊酰基井冈羟胺A(4a￣4c),其结构经1HNMR、IR和MS确认。初步的生物活性测试显示,其中4a和4b均表现出一定的杀蚜虫活性,4b对纹枯病菌也表现出一定的抑制作用。

Three previously unreported 7＇-O-chrysanthemyl validoxylamine A compounds （4a-4c） were synthesized after pyrethrum acylation followed by reacting with validoxylamine A, the hydrolysis product of validamycin A. Their structures were confirmed by MS, ^1H-NMR, and IR spectra. Preliminary biological activity testing showed that 4a and 4b possessed activity against Aphis medicaginis and 4b also was active against Rhizoctonia solani.