丹芍汤治疗阴虚湿热型糖尿病肾病的临床研究

Clinical Study on Dan Shao Tang in Treating Diabetic Nephropathy of Deficiency of Yin with Damp-heat Symptom

目的:探讨丹芍汤对阴虚湿热型糖尿病肾病的作用。方法:72例中医辨证为阴虚湿热型的糖尿病肾病随机分成两组,治疗组42例以丹芍汤加西药治疗,对照组30例单用西药治疗,观察两组治疗前和治疗3个月后的疗效及血糖、肾功能、蛋白尿、尿系列微量蛋白、血脂及血液粘度等指标的变化情况。结果:治疗组总有效率为76.19%,明显优于对照组50.00%(P<0.01);且治疗组在改善症状及肾功能,降低血糖、蛋白尿和尿系列微量蛋白,改善血脂代谢及血液高凝状态等方面均明显优于对照组(P<0.01或P<0.05)。结论:丹芍汤能有效治疗阴虚湿热型糖尿病肾病。

Objective ： To explore the effect of Dan Shao Tang （DST） in treating diabetic nephropathy （DN） of deficiency of Yin with damp-heat symptom. Methods： The 72 patients with DN of deficieny of Yin with damp-heat symptom were randomly divided into two groups. Among them, the 42 patients in treatment group were treated with DST and western medicine and the 30 patients in control group were treated only with western medicine. Before and after treatment, the effect and indexes change including blood glucose, renal function, proteinuria, microproteins, lipid metabolism and hyperviscosity were observed. Results： After three months treatment, the general effective rate in treatment group was 76. 19%, which was markedly higher than that in control group （50. 00%, P 〈0. 01 ）. Moreover, treatment group was obviously better than control group on decreasing blood glucose proteinuria and mieroproteins, improving renal function, ameliorating lipuid metabolism and hyperviscosity （ P 〈 0. 01 or P 〈 O. 05 ）. Conclusion： DST is effective ton treatment on DN of deficiency of Yin with damp-heat sympotom.