益气活血汤治疗缺血性脑卒中的临床研究

The clinical research on the treatment of ischemic stroke by Yiqi Huoxue Decoction

目的探讨益气活血汤治疗缺血性脑卒中的临床疗效及其对血液流变学、内皮素(ET)、降钙素基因相关肽(CGRP)的影响。方法300例缺血性脑卒中患者随机分为试验组和对照组,每组各150例,在常规治疗基础上(降颅压、护脑),试验组口服益气活血汤,对照组口服尼莫地平。结果1.试验组:基本痊愈率52%,显效率22%,有效率16%,无效率10%,总有效率90%。对照组:基本痊愈率44%,显效率18%,有效率16%,无效率22%,总有效率78%,经R分析有显著性差异(P<0.05)。2.试验组血液流变学、ET、CGRP变化与对照组比较有显著性差异(P<0.05)。3.试验组肝肾功能变化与对照组比较无显著性差异(P>0.05)。结论益气活血汤治疗缺血性脑卒中临床疗效优于尼莫地平。

Objective To study therapeutic effect and influence of ET, CGRP and hemorrheologic parameters of Yiqi Huoxue Decoction on ischemic stroke. Methods 300 cases of ischemic stroke patients were randomly divided into treatment group and control group. On base of routine treatment, the treatment group was treated with oral Yiqi Huoxue Decoction; the control group was treated with oral Nimodipine capsule. Results 1. The total effective rates were 90% and 78% in treatment group and control group respectively. There was a significant difference between the two groups. 2. There were significant differences before and after therapy in hemorrheologic parameters, ET, CGRP in treatment group and control group （P〈0.05）. 3. There was no difference before and after therapy in LFT and KFY between the two groups. Conclusion Efficiency of Yiqi Huoxue Decoction is better than Nimodipine capsule.