摘要
目的:考察及筛选加替沙星分散片的制备工艺和最优处方。方法:通过系列试验筛选崩解剂等辅料,确定处方及制备工艺;测定并比较了分散片及普通片剂中主药的溶出度。结果:确定了以羧甲基淀粉钠、交联聚乙烯吡咯烷酮作为崩解剂的分散片处方;分散片溶出速度较普通片更快。结论:研制的加替沙星分散片处方合理、工艺可行,符合分散片的质量要求。
OBJECTIVE： To optimize the preparation technics and the formula of gatifloxacin dispersible tablets. METHODS： The adjuvant like disintegrant etc., the formula and preparation process were optimized by a series of experiments. The dissolution rates of the principal agent in dispersible tablet and conventional tablet were determined and compared. RESULTS： Sodium carboxymethyl starch and crospolyvinylpyrrolidone were optimized as the disintegrants of the dispersible tablet formula; The dissolution rate of the dispersible tablet was faster than that of the conventional tablet. CONCLUSIONS： The prepared gatifloxacin dispersible tablet is reasonable in formula, feasible in technology and it meets the quality standards.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第9期659-662,共4页
China Pharmacy
关键词
加替沙星
分散片
处方
制备工艺
Gatifloxacin
Dispersible tablets
Formula
Preoaration technics
