阿洛西林与他唑巴坦联用对168株致病菌的体外抑菌活性研究

In Vitro Antibacterial Activity of Azlocillin in Combination with Tazobactam against 168 Strains of Pathogenic Bacteria

目的:观察阿洛西林单用及与他唑巴坦联用后对临床分离的168株致病菌的体外抑菌活性。方法:采用二倍稀释法,检测2种抗菌药物对168株临床分离的致病菌的体外抑菌活性。结果:阿洛西林/他唑巴坦(4∶1)MIC50、MIC90值分别是阿洛西林单用的1/32、1/64。结论:阿洛西林与他唑巴坦联用后抑菌活性显著提高。

OBJECTIVE： To compare the in vitro antibacterial activity of azloeillin given alone with azlocillin plus tazobactam against 168 strains of clinically isolated pathogenic bacteria.METHODS：The antibacterial activities of two antibacterials against 168 strains of clinically isolated pathogenic bacteria in vitro were detected by two fold dilution method. RESULTS： The MIC50 and the MIC90 of the combined therapy of azlocillin/tazobactam（4 ： 1） were 1/32 and 1/64, respectively that of azlocillin given alone,CONCLUSION：The concomitant therapy of azloeillin with tazobactam improves the antibacterial activity.