96例新生儿缺氧缺血性脑病血糖监测及其临床意义

Clinical Significance of Detecting Blood Sugar in Neonates with Hypoxic Ischemic Encephalopathy

目的探讨新生儿缺氧缺血性脑病(HIE)血糖水平异常与临床分度的关系,评价血糖水平监测对判断病情及预后的意义。方法对96例HIE新生儿入院及出生后24、48 h采用葡萄糖氧化酶法测定血糖水平。结果HIE分度越重,血糖异常发生率越高,持续时间越长;轻中度HIE血糖异常以低血糖为主,重度HIE血糖异常以高血糖为主,且血糖与临床分度成正比。结论HIE患儿可出现糖代谢紊乱,血糖水平愈高,预后愈差,故HIE应常规监测血糖,以便及时纠正,减轻后遗症。

Objective To investigate the relationship between the level of blood sugar and clinical grade of neonatal hypoxic ischemic encephalopathy （ HIE）, and evaluate the significance of detecting blood sugar on judging patients＇ condition and prognosis. Methods The level of blood sugar of 96 newborn infants with HIE was detected by the glucose oxidase method after born 24, 48 hours. Results The patients＇ condition was severer, the abnormal ratio of blood sugar was higher, the duration was longer. Mild and moderate HIE was hypoglycemia, severe HIE was hyperglycemia. The abnormal level of blood sugar was positive correlation to the clinical grade of HIE. Conclusions The newborn infant with HIE may have the disorder of glycometabolism, the level of blood sugar is higher, the patients＇ condition is severer. The detection of blood sugar in newborn infants can release the sequelae and improve the prognosis.