六味地黄丸对绝经期后反复尿路感染防治作用的临床研究

Prevention and Cure Effect of Liuwei Dihuang Pill on Repeat Urinary Tract Infection of Patients after Menopause

目的探讨六味地黄丸对绝经期后反复尿路感染的防治作用。方法采用随机对照方法, 将符合标准的68例分为治疗组和对照组,治疗组36例,口服六味地黄丸(浓缩丸),对照组32例,口服谷维素,观察2个月。两组均予对症处理。结果治疗组尿路感染次数显著减少(P<0．05),对照组变化不大(P>0．05),且治疗组尿感次数显著低于对照组(P<0．01);治疗中每次尿感时近期治愈时间,治疗组显著短于对照组(P<0．01);治疗组中医证候积分值较治疗前下降显著(P<0．01),且其下降幅度亦显著优于对照组(P<0．01);尿SIgA及血雌二醇水平,治疗组均提高显著(P<0．01),而对照组变化不明显 (P>0．05)。结论六味地黄丸对绝经期后反复尿路感染有显著的预防与治疗作用．值得临床推广应用。

Objective： To study revention and cure effect of Liuwei Dihuang pill on repeat urinary tract infection of patients after menopause. Methods： Sixty-eight patients meet to criteria were divided into treatment group and control group according to random principle. Thirty-six patients in treatment group orally took Liuwei Dihuang Pill, and 32 patients in control group orally took Gammariza. The treatment lasted for 2 months. Results： Compared to control group and before treatment, the number of urinary tract infection decreased significantly （P〈0.05 and P〈0.01）. In treatment group, the cure time after infection and syndrome score of TCM decreased obviously after treatment, which were lower than that of control group（P〈0.01）. The content of SIgA in urinary and destradiol in blood of treatment group increased obviously after treatment compared to those of before treatment, but the two indexes had no significant changes in control group （P〈0.05）. Conclusion： The Liuwei Dihuang pill posses marked prevention and cure effect on repeat urinary tract infection of patients after menopause.