产超广谱β-内酰胺酶的大肠埃希菌检测及其药敏结果分析

ESBLs-producing Escherichia coli and Its Drug Susceptibility Profiles

目的了解某院产超广谱β-内酰胺酶(ESBLs)大肠埃希菌的检出及耐药情况。方法采用微生物生化、药敏试验卡,超广谱β-内酰胺酶试验卡及纸片扩散法对32例大肠埃希菌标本进行ESBLs检测,并对其药敏试验结果进行分析。结果从32株大肠埃希菌中经过确认试验,共检出产ESBLs大肠埃希菌8株,检出率为25.0%。药敏试验耐药率高,敏感性较高的只有美洛培南、哌拉西林/他唑巴坦等抗菌药物。结论产ESBLs的大肠埃希菌检出率较高,对大多数抗菌药物呈现多重耐药,需引起临床的高度重视。

Objective To analysis the antibiotic resistant patterns and isolates of E, coli that producing extendedspectrum beta- lactamases （ESBLs） in our hospital, Methods Thirty - two E, coli isolates in our hospital were tested with test cards for biochemical identification and antibiotic susceptibility, Isolates that produced ESBLs were detected by test card for extended spectrum beta - lactamase and plate diffusion method. The results of antibiotic susceptibility were analyzed. Results Out of the 32 isolates of E. coil, 8 strains yielded ESBLs （2.5.0 % ）. These strains with ESBLs were highly resistant to most common available antibiotics, but only sensitive to Meropenem, Piperacillin/Tazobactam, Conclusion The test results showed that the isolates of E, coil with ESBLs were high. E. coil with ESBLs exhibited highly cross-resistant to a wide range of antibiotic drugs. Therefore, it is very important to identify these strains with ESBLs for the clinical treatment.