组织因子与急性冠脉综合征研究进展

Tissue Factor in Acute Coronary Syndrome

组织因子作为FⅦ/FⅦa的细胞膜表面受体,是外源性凝血系统的关键因子,组织因子通过介导凝血激活形成血栓。动脉粥样硬化斑块破裂处血栓形成是急性冠脉综合征的主要原因,其临床后果的严重性决定于血栓的范围和进展。急性冠脉综合征时循环单核细胞和微颗粒表达组织因子,促进全身的促凝活性。动脉粥样硬化斑块中巨噬细胞、平滑肌细胞、血管内皮细胞表达组织因子,不稳定性斑块中组织因子表达和活性较稳定性斑块更高。组织因子通路抑制物是内源性组织因子抑制物,对调剂血栓形成有重要作用。现就目前组织因子与急性冠脉综合征研究进展作一综述。

Tissue factor （TF） is a receptor for factor FⅦ/FⅦa on a cell surface. It is an important initiator of the exdogenous coagulation cascade, and TF activates exdogenous coagulation cascade and causes thrombosis. The formation of thrombosis at the site of atherosclerotic plaque disruption is the principle cause of acute coronary syndrome. The severity of the clinical consequences is determined by the extent and progression of thrombus. In acute coronary syndromes, circulating monocytes and microparticles indicate TF and contribute to systemic procoagulant activity. Macrophages, smooth muscle cells, and endothelial cells can be an induced indication of TF in atherosclerotie plaques, and rates of TF expression and activity are higher in unstable plaques than in stable plaques. Tissue factor pathway inhibitor （ TFP1） is the endogenous inhibitor of TF and the role of TFP1 is important for regulating the thrombus formation. This article discusses the role of TF in acute coronary syndrome.