肾素-血管紧张素系统与再狭窄的研究进展被引量：2

The Renin-angiotensin System and In-stent Restenosis

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摘要肾素-血管紧张素系统对细胞生长增殖具有重要的调节作用,在支架术后再狭窄的发生中起着十分重要的作用,应用转换酶抑制剂和血管紧张素Ⅱ型受体拮抗剂对肾素-血管紧张素系统进行干预对再狭窄的发生产生矛盾结果,对再狭窄的病理生理、肾素-血管紧张素系统在再狭窄中的作用及对肾素-血管紧张素系统进行干预防治再狭窄的可能作用进行综述。 The renin-angiotensin system （RAS） can regulate smooth muscle cell （SMC） proliferation and migration, and play an important role in in-stent restenosis. There are contradictory effects of preventing in-stent restenosis to inhibit RAS by angiotensin-converting enzyme inhibitors and angiotensin iI type 1 receptor blockers. This review discusses the pathophysiology of in-stent restenosis, the role of the RAS in in-stent restenosis, and the possible role of RAS intervention in the prevention of in-stent restenosis.

作者李贵华贾三庆王雷

机构地区首都医科大学附属北京友谊医院心脏中心

出处《心血管病学进展》 CAS 2006年第3期340-342,共3页 Advances in Cardiovascular Diseases

关键词肾素-血管紧张素系统干预支架内再狭窄 renin-angiotensin system intervention in-stent restenosis

分类号 R541.4 [医药卫生—心血管疾病]

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