左旋精氨酸对兔右冠状动脉缺血再灌注心律失常的影响

目的研究左旋精氨酸(L-Arg)对兔右冠脉缺血再灌注(IR)致心律失常的影响。方法建立兔右冠脉IR模型,将48只兔随机分为IRa组(缺血30min再灌120min)、IRb组(缺血90min再灌120min)、IRa+L-Arg组、IRb+L-Arg组,记录心电图,计算心律失常评分与时间依赖关系,分析L-Arg干预的效果。结果1缺血期:随缺血时间延长,各组心律失常分数逐渐增加,出现不同程度的房室传导阻滞(AVB)、窦性及房性心律失常。2再灌注期:AVB发生次数减少,窦性及房性心律失常逐渐恢复窦性心律;不同时段心律失常评分IRa组显著低于IRb组、IRa+L-Arg组和IRb+L-Arg组明显低于IRa和IRb组、IRa+L-Arg组显著低于IRb+L-Arg组。结论补充L-Arg具有抗右冠脉缺血所致的心律失常作用;缺血时间越长,L-Arg抗再灌注心律失常作用越差。

Objective： To investigate the effect of L-arginine （L-Arg） on the arrhythmia induced by ischemiareperfusion （I-R） of right coronary artery in rabbits. Methods： I-R models were established by occluding and loosening the root of the right coronary artery in rabbits, and 48 heathy adult rabbits were randomly divided into： IRa group （120 rain reperfusion after 30 min ischemia）, IRb group （120 rain reperfusion after 90 rain ischemia）, IRa＋ L-Arg group and IRb＋ L-Arg group. The changes of ECG and arrhythmia were recorded and graded. Results： ① During the ischemia period,the longer time of IR was,the higer score of the arrhythmia was. The incidence of atrial-ventricular block （AVB）, sinus-atrial block （SAB）, even sinus arrest were detected and aggravated gradually. ② During the reperfusion period, AVB incidence declined, some of sinus and atrial arrhythmia was transformed into sinus rhythm gradually. Rrhythmia scores in IRa group were significantly lower than those in IRb group at different phases, IRa ＋ L-Arg group and IRb＋ L-Arg group were significantly lower than those in IRa and IRb groups, and IRa＋ L-Arg group were significantly lower than those in IRb＋ L-Arg group. Conlusions： Supplying appropriate L-arginine is beneficial for inhibiting arrhythmia during I-R ,and the longer the time of ischemia is,the weaker the effect of L-arginine on the arrhythmia present during the period of reperfusion.