特应性与非特应性哮喘的发病机制研究

目的研究炎症细胞及其相关细胞因子、炎性介质在哮喘发病中的作用及相互关系,探讨特应性与非特应性哮喘的发病机制。方法对36例哮喘患者和12例健康者(对照组)进行痰液诱导,对其痰液中的中性粒细胞、嗜酸粒细胞数及白介素4(IL-4)、IL-5、IL-8、髓过氧物酶(MPO)进行检测。结果哮喘组中重度患者痰液中嗜酸粒细胞和中性粒细胞数均高于轻度患者及对照组。IL-4和IL-8水平除缓解期患者与对照组比较无统计学差异外,其余均有统计学意义(P<0.05)。哮喘组中重度患者MPO与其余比较有统计学差异;哮喘组轻度患者与对照组比较统计学差异显著(P<0.01)。结论特应性哮喘的发病机制与诱导痰中嗜酸粒细胞数相关;非特应性哮喘与中性粒细胞数相关。

Objective： To observe the effects and the correlations of the inflammatory cells, the related cytokines and the inflammation mediates on asthma, then investigates the mechanism of the atopy and the nonatopy asthma. Methods： The sputum was induced from 36 asthmatic patients and 12 healthy subjects and then the inflammatory cells, IL-4, IL-5, IL-8 and myelopeoxidase （MPO） levels were detected. Results： The number of neutrophil and eosinophil in the severe exacerbation asthma group was higher than that in the mild exacerbation group, the remission group and the control group. In the levels of IL-4 and IL-8, each group was significantly different from other group except the remission and the control group （P〈0.05） Compared to other groups, the MPO level in the severe exacerbation group had a significant difference and even the mild exacerbation group had a significant difference compared to the control group （P〈0.01）. Conclusions： The atopy asthma was correlated with the number of the eosinophil while the non-atopy with the neutrophil.