靶控输注丙泊酚在癫痫病灶切除术中对皮层脑电图的影响

Effects of target controlled infusion of propofol on electrocorticography during epileptic foci resection

目的观察不同浓度下的靶控输注（TCI）丙泊酚在癫痫病灶切除术中对皮层脑电图（ECoG）的影响。方法在咪唑安定、丙泊酚、芬太尼和维库溴胺诱导和维持的全身麻醉下，22例接受癫痫病灶切除术的患者在切开硬脑膜暴露脑皮质后，先后在丙泊酚靶浓度为1．5、3、4．5μg／ml时，通过ECoG描记脑电波，观察并分析ECoG变化特点。结果与丙泊酚靶浓度1．5μg／ml时相比，3μg／ml时ECoG的α波频率增加至9～10Hz／s，所描记的棘慢波无明显变化；4．5μg／ml时ECoG的α波频率增加至11～12Hz／s，可见低波幅的β波，棘慢波明显减少，但没有完全被抑制。结论合适靶浓度丙泊酚TCI是癫痫手术病人麻醉的良好选择。

Objective To investigate the effects of target controlled infusion （TCI） of propofol on electrocorticography （ECoG） during epileptic loci resection. Methods Twenty-two. epileptic patients undergoing epileptic loci resection were anesthetized with intravenous midazolam, propofol, fentanyl, and vecuronium. After exposure of brain cortex, ECoG was recorded and analyzed under general anesthesia with TCI of different concentrations of propofol 1.5, 3, and 4. 5 μg/ml. Results The frequency of αwave was somewhat accelerated and the epileptic pike-wave complexes were retained. Conclusion TCI of propofol can be used as a good choice for the patients undergoing epileptic loci resection patients.